Why decide between meatloaf and mac and cheese when you can have both in one spectacular dish? Mac and Cheese Meatloaf Casserole features a savory, seasoned meatloaf base baked directly underneath a layer of creamy, homemade macaroni and cheese. The meat juices baste the pasta from the bottom while the cheese sauce melts down into the beef, creating a flavor explosion in every bite. It’s the ultimate comfort food mashup.
Why You’ll Love This Recipe
Two Classics in One
This dish combines the hearty satisfaction of meatloaf with the gooey indulgence of mac and cheese. It’s a fun, crowd-pleasing meal that feels special but is easy to pull together. The textures—dense meatloaf and soft, cheesy pasta—complement each other perfectly.
Homemade Quality
Forget the blue box. The homemade cheese sauce is simple to make and tastes infinitely better. Paired with a meatloaf that is seasoned with onions, garlic, and herbs, this is a high-quality meal that will impress your family or dinner guests.

Ingredients
- 1.5 lbs ground beef
- 1 cup breadcrumbs
- 1 large egg
- 8 oz elbow macaroni
- 2 cups cheddar cheese, shredded
- 2 cups milk
- 2 tbsp butter
- 2 tbsp flour
Instructions
- Mix beef, crumbs, egg, and spices. Press into dish. Bake 20 mins at 375°F.
- Make cheese sauce with butter, flour, milk, and cheese. Toss with cooked pasta.
- Drain meatloaf grease. Top with mac and cheese.
- Bake 15-20 mins more. Rest before slicing.
Nutrition
Ingredient Highlights & Substitutions
Essential Ingredients
Ground Beef: 80/20 lean-to-fat ratio keeps the meatloaf juicy.
Breadcrumbs & Egg: To bind the meatloaf.
Elbow Macaroni: The classic pasta shape.
Cheddar Cheese: Sharp cheddar cuts through the richness.
Milk & Butter: For the béchamel cheese sauce.
Ketchup/BBQ Sauce: A thin glaze between the layers adds tang.
Smart Substitutions
Ground turkey or pork can be used for the meatloaf. You can use any short pasta shape like shells or cavatappi. If you want a spicy kick, add diced jalapeños to the cheese sauce.
Step-by-Step Instructions
Prep Phase
Preheat oven to 375°F (190°C). Grease a 9×13 baking dish. Boil the macaroni.
Cooking Phase
Meatloaf: Mix beef, breadcrumbs, egg, milk, onion, and spices. Press into the bottom of the dish. Spread a thin layer of ketchup on top. Bake for 20 minutes.
Mac & Cheese: Melt butter, whisk in flour, add milk, and simmer until thick. Melt in cheese. Toss with cooked pasta.
Assembly: Drain excess grease from meatloaf. Pour mac and cheese over the top.
Finish: Bake for another 15-20 minutes until bubbly. Let rest 10 minutes before slicing.
Pro Tips for Perfect Results
Technique Secrets
Par-baking the meatloaf is essential. If you put the mac and cheese on raw meat, the pasta will overcook by the time the beef is done. Also, letting it rest is mandatory to get clean slices.
Common Mistakes to Avoid
Overcooking the pasta. Boil it 2 minutes less than package directions so it finishes perfectly in the oven.
| Nutrient | Amount per Serving |
|---|---|
| Calories | 650 kcal |
| Protein | 35g |
| Carbohydrates | 45g |
| Fat | 35g |
Serving Ideas & Pairings
Presentation & Plating
Slice into squares. Garnish with parsley.
Pairing Suggestions
Serve with steamed broccoli to balance the heaviness. If you love cheesy beef dishes, try our Cheesy Ground Beef and Rice Casserole for a rice-based version.
Frequently Asked Questions
Q1? Can I make it ahead?
Yes, assemble and refrigerate. Bake for 10 extra minutes.
Q2? Can I use boxed mac?
Yes, use 2 boxes prepared.
Q3? Why is it greasy?
Drain the meatloaf after the first bake!
Conclusion
Mac and Cheese Meatloaf Casserole is the ultimate indulgence. It’s hearty, cheesy, and absolutely delicious.
